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KMID : 0370219870310040219
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Yakhak Hoeji
1987 Volume.31 No. 4 p.219 ~ p.223
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Synthesis of 4-Hydroxy-2-Methyl-N-(Cyclohexyl)-2H-1,2-Benzothiazine-3-Carboxamide-1,1-Dioxide via 1,3-Oxazine Compounds
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서정진/Suh JJ
홍유화/Hong YH
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Abstract
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2-Cyclohexylimino-3-cyclohexyl-5-methyl-4-oxo-2H,5H-1,3-oxazino[5,6-C]-1,2- benzothiazine-6,6-dioxide 2 was hydrolized in d-HCl/CH3CN to give 5-methyl-3-cyclohexyl-2H,5H-1,3-oxazino[5,6-C]-1,2 benzothiazine-2,4(3H)-dione 6,6-dioxide 3 in 82% yield. The alkaline hydrolysis of 3 afforded to 4-hydroxy-2-methyl-N-(cyclohexyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide 4 in 88% yield. On the other hand 3 was synthesized from 4 and ethylchloroformate on the reversed procedure.
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